Towards Integrated Drug Substance and Drug Product Design for an Active Pharmaceutical Ingredient Using Particle Engineering
نویسندگان
چکیده
منابع مشابه
Integration of active pharmaceutical ingredient solid form selection and particle engineering into drug product design.
This review seeks to offer a broad perspective that encompasses an understanding of the drug product attributes affected by active pharmaceutical ingredient (API) physical properties, their link to solid form selection and the role of particle engineering. While the crucial role of active pharmaceutical ingredient (API) solid form selection is universally acknowledged in the pharmaceutical indu...
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هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...
15 صفحه اولEnantiomeric Separation of Levofloxacin in Drug Product and Drug Substance Using Chiral Stationary Phase
A chiral liquid chromatographic method was developed for the enantiomeric purity of Levofloxacin in drug substance as well as in drug product. The chromatographic separation was achieved on Chiralpak IC 150 X 2.1mm X 5μm, column using a mobile phase system consisting of n-hexane and isopropyl alcohol in the ratio of 95:5 (v/v). The mobile phase was pumped through column at the flow rate of 1 mL...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2011
ISSN: 1530-9932
DOI: 10.1208/s12249-011-9582-5